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236  structures 804  species 15  interactions 14080  sequences 144  architectures

Clan: Cyclin (CL0065)

Summary

Cyclin-like superfamily Add an annotation

This Clan contains cyclins, Transcription factor IIB (TFIIB), and the Retinoblastoma tumour suppressor proteins. These were predicted to be related by sequence [1].

This clan contains 7 families and the total number of domains in the clan is 14080. The clan was built by A Bateman.

Literature references

  1. Gibson TJ, Thompson JD, Blocker A, Kouzarides T; , Nucleic Acids Res 1994;22:946-952.: Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107. PUBMED:8152925 EPMC:8152925
  2. Noble ME, Endicott JA, Brown NR, Johnson LN; , Trends Biochem Sci 1997;22:482-487.: The cyclin box fold: protein recognition in cell-cycle and transcription control. PUBMED:9433129 EPMC:9433129

Members

This clan contains the following 7 member families:

CDK5_activator Cyclin Cyclin_C Cyclin_N RB_A RB_B TFIIB

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cyclin_N (PF00134) 6213 (44.1%) View
Cyclin_C (PF02984) 3032 (21.5%) View
TFIIB (PF00382) 2462 (17.5%) View
Cyclin (PF08613) 1457 (10.3%) View
RB_A (PF01858) 366 (2.6%) View
RB_B (PF01857) 352 (2.5%) View
CDK5_activator (PF03261) 198 (1.4%) View
Total: 7 Total: 14080 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 15 interactions for this clan. More...

Interacting families
A B
Cyclin Pkinase
Cyclin
RB_B RB_A
Cyclin_C Pkinase
Cyclin_N
Cyclin_C
TFIIB TBP
TFIIB
RB_A RB_B
Cyclin_N Pkinase
Cyclin_N
CDI
Cyclin_C
K-cyclin_vir_C
Herp-Cyclin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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