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253  structures 2754  species 8  interactions 10562  sequences 73  architectures

Clan: Cystine-knot (CL0079)

Summary

Cystine-knot cytokine superfamily Add an annotation

The cytokine families in this clan have the cystine-knot fold. In this 6 cysteines form three disulphide bridges that are interlinked.

This clan contains 9 families and the total number of domains in the clan is 10562. The clan was built by A Bateman.

Literature references

  1. Sun PD, Davies DR; , Annu Rev Biophys Biomol Struct 1995;24:269-291.: The cystine-knot growth-factor superfamily. PUBMED:7663117 EPMC:7663117
  2. McDonald NQ, Hendrickson WA; , Cell 1993;73:421-424.: A structural superfamily of growth factors containing a cystine knot motif. PUBMED:8490958 EPMC:8490958

Members

This clan contains the following 9 member families:

Coagulin Cys_knot DAN Hormone_6 NGF Noggin PDGF Sclerostin TGF_beta

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NGF (PF00243) 3765 (35.6%) View
TGF_beta (PF00019) 3712 (35.1%) View
Cys_knot (PF00007) 1416 (13.4%) View
PDGF (PF00341) 855 (8.1%) View
DAN (PF03045) 362 (3.4%) View
Hormone_6 (PF00236) 201 (1.9%) View
Noggin (PF05806) 133 (1.3%) View
Sclerostin (PF05463) 114 (1.1%) View
Coagulin (PF02035) 4 (0.0%) View
Total: 9 Total: 10562 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 8 interactions for this clan. More...

Interacting families
A B
PDGF PDGF
Coagulin Coagulin
NGF TNFR_c6
NGF
TGF_beta TGF_beta
Kazal_1
Activin_recp
PRKCSH

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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