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12  structures 5620  species 0  interactions 114318  sequences 341  architectures

Clan: DMT (CL0184)

Summary

Drug/Metabolite transporter superfamily Add an annotation

This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit [1]. Many of these families contain a characteristic glycine rich motif close to the C-terminus.

This clan contains 20 families and the total number of domains in the clan is 114318. The clan was built by A Bateman.

Literature references

  1. Jack DL, Yang NM, Saier MH Jr; , Eur J Biochem 2001;268:3620-3639.: The drug/metabolite transporter superfamily. PUBMED:11432728 EPMC:11432728
  2. Vastermark A, Almen MS, Simmen MW, Fredriksson R, Schioth HB;, BMC Evol Biol. 2011;11:123.: Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae. PUBMED:21569384 EPMC:21569384

Members

This clan contains the following 20 member families:

Cation_efflux CRCB CRT-like DUF1632 DUF486 DUF606 DUF914 EamA EmrE Mg_trans_NIPA Multi_Drug_Res Nuc_sug_transp RhaT Sugar_transport TPT UAA UPF0060 UPF0546 Ureide_permease Zip

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EamA (PF00892) 66028 (57.8%) View
Cation_efflux (PF01545) 12806 (11.2%) View
Multi_Drug_Res (PF00893) 6822 (6.0%) View
Zip (PF02535) 6416 (5.6%) View
CRCB (PF02537) 5746 (5.0%) View
DUF606 (PF04657) 2941 (2.6%) View
TPT (PF03151) 2906 (2.5%) View
EmrE (PF13536) 1585 (1.4%) View
UAA (PF08449) 1443 (1.3%) View
Mg_trans_NIPA (PF05653) 1396 (1.2%) View
UPF0060 (PF02694) 1396 (1.2%) View
Sugar_transport (PF06800) 1288 (1.1%) View
Nuc_sug_transp (PF04142) 1158 (1.0%) View
RhaT (PF06379) 639 (0.6%) View
DUF486 (PF04342) 583 (0.5%) View
DUF914 (PF06027) 558 (0.5%) View
UPF0546 (PF10639) 235 (0.2%) View
DUF1632 (PF07857) 180 (0.2%) View
Ureide_permease (PF07168) 165 (0.1%) View
CRT-like (PF08627) 27 (0.0%) View
Total: 20 Total: 114318 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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