Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1170  structures 3113  species 24  interactions 56360  sequences 2215  architectures

Clan: EF_hand (CL0220)

Summary

EF-hand like superfamily Add an annotation

The EF hand is a calcium binding domain found in a wide variety of proteins [1].

This clan contains 16 families and the total number of domains in the clan is 56360. The clan was built by A Bateman.

Literature references

  1. Yap KL, Ames JB, Swindells MB, Ikura M; , Proteins. 1999;37:499-507.: Diversity of conformational states and changes within the EF-hand protein superfamily. PUBMED:10591109 EPMC:10591109

Members

This clan contains the following 16 member families:

Caleosin Dockerin_1 EF-hand_1 EF-hand_10 EF-hand_2 EF-hand_3 EF-hand_4 EF-hand_5 EF-hand_6 EF-hand_7 EF-hand_8 EF-hand_9 EF-hand_like EFhand_Ca_insen S_100 SPARC_Ca_bdg

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EF-hand_7 (PF13499) 22951 (40.7%) View
EF-hand_8 (PF13833) 8724 (15.5%) View
EF-hand_6 (PF13405) 5737 (10.2%) View
EF-hand_5 (PF13202) 5306 (9.4%) View
EF-hand_1 (PF00036) 3781 (6.7%) View
EF-hand_4 (PF12763) 2526 (4.5%) View
Dockerin_1 (PF00404) 1647 (2.9%) View
EF-hand_like (PF09279) 1479 (2.6%) View
S_100 (PF01023) 1006 (1.8%) View
EF-hand_2 (PF09068) 673 (1.2%) View
SPARC_Ca_bdg (PF10591) 665 (1.2%) View
EF-hand_3 (PF09069) 641 (1.1%) View
EFhand_Ca_insen (PF08726) 640 (1.1%) View
Caleosin (PF05042) 275 (0.5%) View
EF-hand_10 (PF14788) 227 (0.4%) View
EF-hand_9 (PF14658) 82 (0.1%) View
Total: 16 Total: 56360 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 24 interactions for this clan. More...

Interacting families
A B
EF-hand_like C2
PI-PLC-Y
PI-PLC-X
EF-hand_2 WW
EF-hand_3
S_100 EF-hand_1
S_100
EF-hand_3 EF-hand_2
EFhand_Ca_insen EF-hand_1
Myosin_head
IQ
EFhand_Ca_insen
Dockerin_1 Dockerin_1
Cohesin
EF-hand_1 EF-hand_1
Myosin_head
Metallophos
FKBP_C
IQ
Troponin
S_100
Myosin_N
EFhand_Ca_insen
Shal-type

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...