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362  structures 5503  species 23  interactions 37176  sequences 461  architectures

Clan: Fer2 (CL0486)

Summary

2Fe-2S iron-sulfur cluster binding domain Add an annotation

The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domani is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.

This clan contains 5 families and the total number of domains in the clan is 37176. The clan was built by A Bateman.

Literature references

  1. Armengaud J, Sainz G, Jouanneau Y, Sieker LC;, Acta Crystallogr D Biol Crystallogr. 2001;57:301-303.: Crystallization and preliminary X-ray diffraction analysis of a [2Fe-2S] ferredoxin (FdVI) from Rhodobacter capsulatus. PUBMED:11173487 EPMC:11173487

Members

This clan contains the following 5 member families:

DHODB_Fe-S_bind Fer2 Fer2_2 Fer2_3 Fer2_4

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Fer2 (PF00111) 17474 (47.0%) View
Fer2_2 (PF01799) 5947 (16.0%) View
Fer2_4 (PF13510) 5655 (15.2%) View
Fer2_3 (PF13085) 5265 (14.2%) View
DHODB_Fe-S_bind (PF10418) 2835 (7.6%) View
Total: 5 Total: 37176 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 23 interactions for this clan. More...

Interacting families
A B
Fer2 Cytochrom_C
Fer4
Fer2
NAD_binding_1
FAD_binding_2
FAD_binding_5
FAD_binding_6
Sdh_cyt
Ald_Xan_dh_C
Fer2_2
Fe_hyd_SSU
Ald_Xan_dh_C2
Succ_DH_flav_C
FeThRed_B
CO_deh_flav_C
Fer2_2 Fer2
FAD_binding_5
Ald_Xan_dh_C
Ald_Xan_dh_C2
CO_deh_flav_C
DHODB_Fe-S_bind NAD_binding_1
FAD_binding_6
DHO_dh

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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