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370  structures 4952  species 6  interactions 24576  sequences 93  architectures

Clan: Form_Glyc_dh (CL0325)

Summary

Formate/glycerate dehydrogenase catalytic domain-like superfamily Add an annotation

This superfamily includes the catalytic domain of a variety of dehydrogenase enzymes. The domain has a flavodoxin-like fold and contains an inserted Rossman fold NAD-binding domain.

This clan contains 3 families and the total number of domains in the clan is 24576. The clan was built by A Bateman.

Members

This clan contains the following 3 member families:

2-Hacid_dh AdoHcyase AlaDh_PNT_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
2-Hacid_dh (PF00389) 16860 (68.6%) View
AlaDh_PNT_N (PF05222) 5191 (21.1%) View
AdoHcyase (PF05221) 2525 (10.3%) View
Total: 3 Total: 24576 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 6 interactions for this clan. More...

Interacting families
A B
AlaDh_PNT_N AlaDh_PNT_C
2-Hacid_dh 2-Hacid_dh
ACT
2-Hacid_dh_C
AdoHcyase AdoHcyase_NAD
AdoHcyase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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