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16  structures 4522  species 3  interactions 4847  sequences 17  architectures

Clan: GAD (CL0250)

Summary

GAD domain superfamily Add an annotation

This domain is found as an insert within aspartyl-tRNA synthetase as well as GatB proteins.

This clan contains 2 families and the total number of domains in the clan is 4847. The clan was built by A Bateman.

Literature references

  1. Wolf YI, Aravind L, Grishin NV, Koonin EV; , Genome Res 1999;9:689-710.: Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. PUBMED:10447505 EPMC:10447505

Members

This clan contains the following 2 member families:

GAD GAD-like

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GAD (PF02938) 4662 (96.2%) View
GAD-like (PF08887) 185 (3.8%) View
Total: 2 Total: 4847 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
GAD tRNA-synt_2
GatB_N
GAD

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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