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42  structures 365  species 4  interactions 9451  sequences 410  architectures

Clan: GAP (CL0409)

Summary

GTPase activation domain superfamily Add an annotation

Superfamily contains BCR-homology GTPase activation domain (BH-domain) and p120GAP domain-like, including the GAP related domain of neurofibromin, families.

This clan contains 3 families and the total number of domains in the clan is 9451. The clan was built by RD Finn.

Members

This clan contains the following 3 member families:

DUF1708 RasGAP RhoGAP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RhoGAP (PF00620) 7538 (79.8%) View
RasGAP (PF00616) 1769 (18.7%) View
DUF1708 (PF08101) 144 (1.5%) View
Total: 3 Total: 9451 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
RhoGAP Ras
C1_1
RhoGAP
RasGAP Ras

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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