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49  structures 140  species 3  interactions 2125  sequences 88  architectures

Clan: GF_recep_C-rich (CL0547)

Summary

Growth factor receptor Cys-rich Add an annotation

The cysteine-rich regions of growth factor receptor tyrosine kinases consist of eight disulphide-linked modules [1].

This clan contains 2 families and the total number of domains in the clan is 2125. The clan was built by R Eberhardt.

Literature references

  1. Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW; , Nature 1998;394:395-399.: Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. PUBMED:9690478 EPMC:9690478

Members

This clan contains the following 2 member families:

Furin-like GF_recep_IV

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GF_recep_IV (PF14843) 1237 (58.2%) View
Furin-like (PF00757) 888 (41.8%) View
Total: 2 Total: 2125 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
Furin-like Furin-like
Recep_L_domain
V-set

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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