Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
655  structures 6368  species 14  interactions 81507  sequences 587  architectures

Clan: HHH (CL0198)

Summary

Helix-hairpin-helix superfamily Add an annotation

This superfamily includes Helix-hairpin-helix DNA-binding domains.

This clan contains 20 families and the total number of domains in the clan is 81507. The clan was built by A Bateman.

Literature references

  1. Doherty AJ, Serpell LC, Ponting CP; , Nucleic Acids Res 1996;24:2488-2497.: The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA. PUBMED:8692686 EPMC:8692686
  2. Shao X, Grishin NV; , Nucleic Acids Res 2000;28:2643-2650.: Common fold in helix-hairpin-helix proteins. PUBMED:10908318 EPMC:10908318

Members

This clan contains the following 20 member families:

Cdd1 DNA_pol_lambd_f DUF3173 DUF4332 DUF655 HHH HhH-GPD HHH_2 HHH_3 HHH_4 HHH_5 HHH_6 HHH_7 HHH_8 IMS_HHH PsbU RNA_pol_A_CTD T2SK TfoX_C Transposase_20

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HhH-GPD (PF00730) 13897 (17.1%) View
HHH_5 (PF14520) 12686 (15.6%) View
HHH (PF00633) 8740 (10.7%) View
HHH_3 (PF12836) 8248 (10.1%) View
HHH_6 (PF14579) 7029 (8.6%) View
Transposase_20 (PF02371) 6999 (8.6%) View
RNA_pol_A_CTD (PF03118) 5961 (7.3%) View
HHH_2 (PF12826) 5697 (7.0%) View
IMS_HHH (PF11798) 4693 (5.8%) View
HHH_4 (PF14490) 1795 (2.2%) View
HHH_8 (PF14716) 1491 (1.8%) View
T2SK (PF03934) 1236 (1.5%) View
TfoX_C (PF04994) 1181 (1.4%) View
DNA_pol_lambd_f (PF10391) 544 (0.7%) View
DUF3173 (PF11372) 326 (0.4%) View
HHH_7 (PF14635) 299 (0.4%) View
DUF4332 (PF14229) 244 (0.3%) View
Cdd1 (PF11731) 195 (0.2%) View
DUF655 (PF04919) 157 (0.2%) View
PsbU (PF06514) 89 (0.1%) View
Total: 20 Total: 81507 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 14 interactions for this clan. More...

Interacting families
A B
RNA_pol_A_CTD ArsC
PsbU Photo_RC
PSII
PsbU
HHH HHH
HhH-GPD
ERCC4
Rad51
HhH-GPD HHH
HhH-GPD
AlkA_N
OGG_N
EndIII_4Fe-2S
DNA_pol_lambd_f NTP_transf_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...