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147  structures 4930  species 5  interactions 15333  sequences 99  architectures

Clan: HIT (CL0265)

Summary

HIT superfamily Add an annotation

The HIT superfamily are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides [1].

This clan contains 5 families and the total number of domains in the clan is 15333. The clan was built by A Bateman.

Literature references

  1. Brenner C; , Biochemistry. 2002;41:9003-9014.: Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. PUBMED:12119013 EPMC:12119013

Members

This clan contains the following 5 member families:

CwfJ_C_1 DcpS_C GalP_UDP_tr_C GalP_UDP_transf HIT

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HIT (PF01230) 8213 (53.6%) View
GalP_UDP_transf (PF01087) 2821 (18.4%) View
GalP_UDP_tr_C (PF02744) 2558 (16.7%) View
DcpS_C (PF11969) 1192 (7.8%) View
CwfJ_C_1 (PF04677) 549 (3.6%) View
Total: 5 Total: 15333 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
GalP_UDP_tr_C GalP_UDP_transf
GalP_UDP_tr_C
GalP_UDP_transf GalP_UDP_transf
GalP_UDP_tr_C
HIT HIT

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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