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201  structures 4085  species 2  interactions 13158  sequences 170  architectures

Clan: HSP20 (CL0190)

Summary

HSP20-like chaperone superfamily Add an annotation

The small heat shock proteins (sHSPs) prevent protein aggregation during heat shock and oppose regulated cell death. A conserved arginine residue in the HSP20/alpha-crystallin domain (Pfam:PF00011) has in fact been implicated in the development of cataracts and myopathies [1]. The CS family (Pfam:PF04969) includes proteins that are known to bind HSP90 [2], as well as p23 (Swiss:Q15185), which is an HSP90 co-chaperone [3].

This clan contains 4 families and the total number of domains in the clan is 13158. The clan was built by M Fenech.

Literature references

  1. van Montfort RL, Basha E, Friedrich KL, Slingsby C, Vierling E; , Nat Struct Biol 2001;8:1025-1030.: Crystal structure and assembly of a eukaryotic small heat shock protein. PUBMED:11702068 EPMC:11702068
  2. Lee YT, Jacob J, Michowski W, Nowotny M, Kuznicki J, Chazin WJ; , J Biol Chem 2004;279:16511-16517.: Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. PUBMED:14761955 EPMC:14761955
  3. Weaver AJ, Sullivan WP, Felts SJ, Owen BA, Toft DO; , J Biol Chem 2000;275:23045-23052.: Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. PUBMED:10811660 EPMC:10811660

Members

This clan contains the following 4 member families:

CS GvpH HSP20 PIH1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HSP20 (PF00011) 9881 (75.1%) View
CS (PF04969) 2605 (19.8%) View
PIH1 (PF08190) 646 (4.9%) View
GvpH (PF05455) 26 (0.2%) View
Total: 4 Total: 13158 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
CS CS
HSP20 HSP20

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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