Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
74  structures 4102  species 7  interactions 7665  sequences 240  architectures

Clan: HeH (CL0306)

Summary

LEM/SAP HeH motif Add an annotation

This superfamily includes protein domains with the helix-extended loop-helix (HeH) structure.

This clan contains 5 families and the total number of domains in the clan is 7665. The clan was built by A Bateman.

Literature references

  1. Okubo S, Hara F, Tsuchida Y, Shimotakahara S, Suzuki S, Hatanaka H, Yokoyama S, Tanaka H, Yasuda H, Shindo H; , J Biol Chem. 2004;279:31455-31461.: NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers. PUBMED:15133049 EPMC:15133049

Members

This clan contains the following 5 member families:

Endonuc-dimeris HeH LEM Rho_N SAP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Rho_N (PF07498) 3972 (51.8%) View
SAP (PF02037) 2887 (37.7%) View
LEM (PF03020) 494 (6.4%) View
HeH (PF12949) 275 (3.6%) View
Endonuc-dimeris (PF09124) 37 (0.5%) View
Total: 5 Total: 7665 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
SAP Ku_C
Ku_N
LEM BAF
Thymopoietin
Rho_N Rho_RNA_bind
Rho_N
Endonuc-dimeris Endonuclease_7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...