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124  structures 1212  species 6  interactions 3278  sequences 150  architectures

Clan: Hexosaminidase (CL0546)

Summary

beta-N-acetylhexosaminidase-like domain Add an annotation

This superfamily is characterised by a mixed beta sheet with connection over the free side of the sheet. The fold is like a zincin fold lacking the catalytic centre.

This clan contains 3 families and the total number of domains in the clan is 3278. The clan was built by P Coggill.

Literature references

  1. Golan G, Shallom D, Teplitsky A, Zaide G, Shulami S, Baasov T, Stojanoff V, Thompson A, Shoham Y, Shoham G;, J Biol Chem. 2004;279:3014-3024.: Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications. PUBMED:14573597 EPMC:14573597

Members

This clan contains the following 3 member families:

Glyco_hydro_20b Glyco_hydro_67N Glycohydro_20b2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glyco_hydro_20b (PF02838) 2321 (70.8%) View
Glycohydro_20b2 (PF14845) 633 (19.3%) View
Glyco_hydro_67N (PF03648) 324 (9.9%) View
Total: 3 Total: 3278 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 6 interactions for this clan. More...

Interacting families
A B
Glyco_hydro_67N Glyco_hydro_67C
Glyco_hydro_67M
Glyco_hydro_20b Glyco_hydro_20
Glyco_hydro_20b
CHB_HEX
CHB_HEX_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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