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497  structures 7648  species 12  interactions 242300  sequences 5781  architectures

Clan: His_Kinase_A (CL0025)

Summary

His Kinase A (phospho-acceptor) domain Add an annotation

This is the dimerisation and phospho-acceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536. It is usually found adjacent to a C-terminal ATPase domain (Pfam:PF02518). This domain is found in a wide range of Bacteria and also several Archaea. It comprises one of the fundamental units of the two-component signal transduction system [2-7].

This clan contains 9 families and the total number of domains in the clan is 242300. The clan was built by DJ Studholme.

Literature references

  1. Grebe TW, Stock JB; , Adv Microb Physiol 1999;41:139-227.: The histidine protein kinase superfamily. PUBMED:10500846 EPMC:10500846
  2. Hwang I, Chen HC, Sheen J; , Plant Physiol 2002;129:500-515.: Two-component signal transduction pathways in Arabidopsis. PUBMED:12068096 EPMC:12068096
  3. Lohrmann J, Harter K; , Plant Physiol 2002;128:363-369.: Plant two-component signaling systems and the role of response regulators. PUBMED:11842140 EPMC:11842140
  4. Santos JL, Shiozaki K; , Sci STKE 2001;2001:RE1.: Fungal histidine kinases. PUBMED:11752677 EPMC:11752677
  5. West AH, Stock AM; , Trends Biochem Sci 2001;26:369-376.: Histidine kinases and response regulator proteins in two-component signaling systems. PUBMED:11406410 EPMC:11406410
  6. Rodrigue A, Quentin Y, Lazdunski A, Mejean V, Foglino M; , Trends Microbiol 2000;8:498-504.: Two-component systems in Pseudomonas aeruginosa: why so many?. PUBMED:11121759 EPMC:11121759
  7. Stock AM, Robinson VL, Goudreau PN; , Annu Rev Biochem 2000;69:183-215.: Two-component signal transduction. PUBMED:10966457 EPMC:10966457

Members

This clan contains the following 9 member families:

DUF2328 HATPase_c HATPase_c_2 HATPase_c_3 HATPase_c_5 HisKA HisKA_2 HisKA_3 HWE_HK

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HATPase_c (PF02518) 129386 (53.4%) View
HisKA (PF00512) 79834 (32.9%) View
HisKA_3 (PF07730) 12598 (5.2%) View
HATPase_c_3 (PF13589) 9547 (3.9%) View
HATPase_c_2 (PF13581) 5237 (2.2%) View
HATPase_c_5 (PF14501) 2619 (1.1%) View
HisKA_2 (PF07568) 1811 (0.7%) View
HWE_HK (PF07536) 1003 (0.4%) View
DUF2328 (PF10090) 265 (0.1%) View
Total: 9 Total: 242300 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 12 interactions for this clan. More...

Interacting families
A B
HATPase_c HSP90
DNA_gyraseB
HisKA
DNA_mis_repair
CheW
HATPase_c
H-kinase_dim
FbpA
CDC37_M
Topo-VIb_trans
BCDHK_Adom3
HisKA HATPase_c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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