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394  structures 6221  species 23  interactions 139176  sequences 669  architectures

Clan: Hybrid (CL0105)

Summary

Barrel sandwich hybrid superfamily Add an annotation

This superfamily contains proteins with a hybrid motif [1]. This motif is embedded in structurally diverse proteins.

This clan contains 17 families and the total number of domains in the clan is 139176. The clan was built by A Bateman.

Literature references

  1. Chothia C, Murzin AG; , Structure 1993;1:217-222.: New folds for all-beta proteins. PUBMED:8081735 EPMC:8081735

Members

This clan contains the following 17 member families:

Apocytochr_F_C Biotin_lipoyl Biotin_lipoyl_2 Complex1_51K DUF2118 DUF2254 GCV_H HlyD HlyD_2 HlyD_3 NQRA OEP Peptidase_M23 PTS_EIIA_1 PYNP_C QRPTase_N RnfC_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
OEP (PF02321) 30969 (22.3%) View
Biotin_lipoyl (PF00364) 25099 (18.0%) View
Peptidase_M23 (PF01551) 16518 (11.9%) View
HlyD_2 (PF12700) 15970 (11.5%) View
HlyD (PF00529) 15364 (11.0%) View
PTS_EIIA_1 (PF00358) 7674 (5.5%) View
Complex1_51K (PF01512) 5590 (4.0%) View
HlyD_3 (PF13437) 4655 (3.3%) View
GCV_H (PF01597) 4486 (3.2%) View
QRPTase_N (PF02749) 3866 (2.8%) View
PYNP_C (PF07831) 2815 (2.0%) View
Biotin_lipoyl_2 (PF13533) 2242 (1.6%) View
RnfC_N (PF13375) 1912 (1.4%) View
NQRA (PF05896) 764 (0.5%) View
Apocytochr_F_C (PF01333) 697 (0.5%) View
DUF2254 (PF10011) 512 (0.4%) View
DUF2118 (PF09891) 43 (0.0%) View
Total: 17 Total: 139176 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 23 interactions for this clan. More...

Interacting families
A B
HlyD HlyD
Biotin_lipoyl Biotin_lipoyl
HMGL-like
PYC_OADA
Biotin_carb_C
BCDHK_Adom3
OEP OEP
Apocytochr_F_C Cytochrom_B_C
Cytochrom_B_N
PetG
PetN
PetL
PetM
CytB6-F_Fe-S
PYNP_C Glycos_transf_3
Glycos_trans_3N
QRPTase_N QRPTase_C
QRPTase_N
GCV_H GCV_H
PTS_EIIA_1 PTS_EIIA_1
FGGY_N
PTS-HPr
FGGY_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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