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164  structures 369  species 1  interaction 2025  sequences 12  architectures

Clan: Knottin_1 (CL0054)

Summary

Scorpion toxin-like knottin superfamily Add an annotation

This clan includes a number of toxin families that share the knottin structure. These families come from scorpions, plants and arthropods.

This clan contains 11 families and the total number of domains in the clan is 2025. The clan was built by A Bateman.

Members

This clan contains the following 11 member families:

Defensin_2 DUF2667 Gamma-thionin SCRL SLR1-BP Toxin_17 Toxin_2 Toxin_3 Toxin_37 Toxin_38 Toxin_5

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Gamma-thionin (PF00304) 545 (26.9%) View
Toxin_3 (PF00537) 487 (24.0%) View
Defensin_2 (PF01097) 314 (15.5%) View
SCRL (PF06876) 154 (7.6%) View
Toxin_37 (PF11415) 150 (7.4%) View
SLR1-BP (PF07333) 134 (6.6%) View
Toxin_2 (PF00451) 130 (6.4%) View
Toxin_38 (PF14866) 40 (2.0%) View
Toxin_17 (PF08086) 27 (1.3%) View
Toxin_5 (PF05294) 25 (1.2%) View
DUF2667 (PF10868) 19 (0.9%) View
Total: 11 Total: 2025 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
Toxin_3 Toxin_3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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