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138  structures 12554  species 17  interactions 17032  sequences 141  architectures

Clan: LEF-8-like (CL0410)

Summary

LEF-8 like region of RNA polymerase Rpb2 Add an annotation

Late expression factor 8 (LEF-8) is one of the primary components of RNA polymerase produced by polyhedrosis viruses. LEF-8 shows homology to domain 6 of the second largest subunit of prokaryotic DNA-directed RNA polymerase[1].

This clan contains 2 families and the total number of domains in the clan is 17032. The clan was built by J Mistry and RD Finn.

Literature references

  1. Acharya A, Gopinathan KP; , J Gen Virol 2002;83:2015-2023.: Characterization of late gene expression factors lef-9 and lef-8 from Bombyx mori nucleopolyhedrovirus. PUBMED:12124466 EPMC:12124466

Members

This clan contains the following 2 member families:

LEF-8 RNA_pol_Rpb2_6

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RNA_pol_Rpb2_6 (PF00562) 16703 (98.1%) View
LEF-8 (PF04941) 329 (1.9%) View
Total: 2 Total: 17032 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Interactions

There are 17 interactions for this clan. More...

Interacting families
A B
RNA_pol_Rpb2_6 RNA_pol_Rpb1_2
RNA_pol_A_bac
TFIIS_C
RNA_pol_L
RNA_pol_N
DNA_RNApol_7kD
Sigma70_r3
Sigma70_r4
RNA_pol_Rpb2_7
RNA_pol_Rpb2_1
RNA_pol_Rpb2_3
RNA_pol_Rpb2_5
RNA_pol_Rpb1_3
RNA_pol_Rpb1_1
RNA_pol_Rpb1_5
RNA_pol_Rpb1_4
RNA_pol_Rpb2_45

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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