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68  structures 336  species 2  interactions 2678  sequences 32  architectures

Clan: LIG (CL0532)

Summary

Lipid-binding Ig-like superfamily Add an annotation

This superfamily includes a number of lipid binding families that have a similar topology to the immunoglobulin fold. The family includes The ML domain Pfam:PF02221. It includes the uncharacterised family Pfam:PF06477.

This clan contains 3 families and the total number of domains in the clan is 2678. The clan was built by A Bateman.

Literature references

  1. Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M;, FEBS Lett. 2005;579:1208-1212.: Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity. PUBMED:15710415 EPMC:15710415
  2. Wright CS, Mi LZ, Lee S, Rastinejad F;, Biochemistry. 2005;44:13510-13521.: Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity. PUBMED:16216074 EPMC:16216074

Members

This clan contains the following 3 member families:

DUF1091 E1_DerP2_DerF2 TRP_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DUF1091 (PF06477) 1212 (45.3%) View
E1_DerP2_DerF2 (PF02221) 1034 (38.6%) View
TRP_N (PF14558) 432 (16.1%) View
Total: 3 Total: 2678 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
E1_DerP2_DerF2 LRR_1
E1_DerP2_DerF2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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