Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
250  structures 3145  species 13  interactions 175606  sequences 9511  architectures

Clan: LRR (CL0022)

Summary

Leucine Rich Repeat Add an annotation

Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. This Pfam entry contains Leucine Rich Repeats not recognised by the Pfam:PF00560 model.

This clan contains 11 families and the total number of domains in the clan is 175606. The clan was built by DJ Studholme.

Literature references

  1. Kobe B, Deisenhofer J; , Trends Biochem Sci 1994;19:415-421.: The leucine-rich repeat: a versatile binding motif. PUBMED:7817399 EPMC:7817399
  2. Kobe B, Deisenhofer J; , Nature 1993;366:751-756.: Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. PUBMED:8264799 EPMC:8264799

Members

This clan contains the following 11 member families:

DUF285 FNIP LRR_1 LRR_2 LRR_3 LRR_4 LRR_5 LRR_6 LRR_7 LRR_8 LRR_9

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LRR_8 (PF13855) 70869 (40.4%) View
LRR_6 (PF13516) 30484 (17.4%) View
LRR_1 (PF00560) 25597 (14.6%) View
LRR_4 (PF12799) 21961 (12.5%) View
LRR_5 (PF13306) 12012 (6.8%) View
FNIP (PF05725) 6356 (3.6%) View
LRR_7 (PF13504) 2943 (1.7%) View
DUF285 (PF03382) 2904 (1.7%) View
LRR_9 (PF14580) 1482 (0.8%) View
LRR_3 (PF07725) 609 (0.3%) View
LRR_2 (PF07723) 389 (0.2%) View
Total: 11 Total: 175606 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 13 interactions for this clan. More...

Interacting families
A B
LRR_1 Cadherin
RnaseA
Trypsin
VWA
LRR_1
Sema
LRRNT
TIG
E1_DerP2_DerF2
I-set
RabGGT_insert
LRR_adjacent
Tap-RNA_bind

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...