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10  structures 2158  species 1  interaction 3976  sequences 5  architectures

Clan: LolA_LolB (CL0048)

Summary

Lipoprotein localisation factors LolA/B Add an annotation

Gram-negative bacteria lipoproteins are anchored to the periplasmic surface of the inner or outer membrane depending on the sorting signal, which is the residue at position 2 of the polypeptide. Five Lol proteins are involved in the sorting and membrane localisation of lipoprotein. An ATP-binding cassette (ABC) transporter, LolCDE, releases outer membrane-specific lipoproteins from the inner membrane, causing the formation of a complex between the released lipoproteins and the periplasmic molecular chaperone LolA. When this complex interacts with outer membrane receptor LolB, the lipoproteins are transferred from LolA to LolB and then localised to the outer membrane. The structures of LolA and LolB are remarkably similar to each other. Both have a hydrophobic cavity consisting of an unclosed beta-barrel and an alpha-helical lid [1,2].

This clan contains 2 families and the total number of domains in the clan is 3976. The clan was built by RD Finn.

Literature references

  1. Takeda K, Miyatake H, Yokota N, Matsuyama S, Tokuda H, Miki K; , EMBO J 2003;22:3199-3209.: Crystal structures of bacterial lipoprotein localization factors, LolA and LolB. PUBMED:12839983 EPMC:12839983
  2. Tokuda H, Matsuyama S; , Biochim Biophys Acta 2004;1693:5-13.: Sorting of lipoproteins to the outer membrane in E. coli. PUBMED:15276320 EPMC:15276320

Members

This clan contains the following 2 member families:

LolA LolB

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LolA (PF03548) 2649 (66.6%) View
LolB (PF03550) 1327 (33.4%) View
Total: 2 Total: 3976 Clan alignment
 

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Family relationships

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Species distribution

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
LolB LolB

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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