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22  structures 6356  species 1  interaction 249360  sequences 846  architectures

Clan: MFS (CL0015)

Summary

Major Facilitator Superfamily Add an annotation

The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth [1]. It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity [1]. All permeases of the MFS possess either 12 or 14 transmembrane helices [1].

This clan contains 25 families and the total number of domains in the clan is 249360. The clan was built by A Bateman.

Literature references

  1. Pao SS, Paulsen IT, Saier MH Jr; , Microbiol Mol Biol Rev 1998;62:1-34.: Major facilitator superfamily. PUBMED:9529885 EPMC:9529885

Members

This clan contains the following 25 member families:

Acatn ATG22 BT1 CLN3 DUF1228 DUF791 Folate_carrier FPN1 FTR1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MFS_1 (PF07690) 181668 (72.9%) View
Sugar_tr (PF00083) 32448 (13.0%) View
PTR2 (PF00854) 7665 (3.1%) View
MFS_2 (PF13347) 6648 (2.7%) View
MFS_3 (PF05977) 4536 (1.8%) View
FTR1 (PF03239) 2689 (1.1%) View
Nuc_H_symport (PF03825) 1944 (0.8%) View
OATP (PF03137) 1462 (0.6%) View
ATG22 (PF11700) 1392 (0.6%) View
LacY_symp (PF01306) 1275 (0.5%) View
Nucleoside_tran (PF01733) 1065 (0.4%) View
DUF1228 (PF06779) 952 (0.4%) View
BT1 (PF03092) 726 (0.3%) View
continued
Pfam family Num. domains Alignment
UNC-93 (PF05978) 630 (0.3%) View
Nodulin-like (PF06813) 586 (0.2%) View
TLC (PF03219) 560 (0.2%) View
MFS_1_like (PF12832) 546 (0.2%) View
CLN3 (PF02487) 477 (0.2%) View
Acatn (PF13000) 464 (0.2%) View
Folate_carrier (PF01770) 433 (0.2%) View
FPN1 (PF06963) 342 (0.1%) View
PUCC (PF03209) 317 (0.1%) View
DUF791 (PF05631) 263 (0.1%) View
TRI12 (PF06609) 214 (0.1%) View
MFS_Mycoplasma (PF07672) 58 (0.0%) View
Total: 25 Total: 249360 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
LacY_symp LacY_symp

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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