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347  structures 3218  species 4  interactions 5290  sequences 29  architectures

Clan: MIF (CL0082)

Summary

Tautomerase/MIF superfamily Add an annotation

This clan groups 5-(carboxymethyl)-2-hydroxymuconate isomerase (CHMI) and 4-oxalocrotonate tautomerase (4-OT) with macrophage inhibitory factor (MIF). Interestingly they all share an amino-terminal proline. Members of this clan for homotrimers [1].

This clan contains 6 families and the total number of domains in the clan is 5290. The clan was built by A Bateman.

Literature references

  1. Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J; , Biochemistry 1999;38:3268-3279.: Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. PUBMED:10079069 EPMC:10079069

Members

This clan contains the following 6 member families:

CHMI DUF1904 MIF Tautomerase Tautomerase_2 Tautomerase_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Tautomerase (PF01361) 2760 (52.2%) View
CHMI (PF02962) 831 (15.7%) View
MIF (PF01187) 669 (12.6%) View
Tautomerase_2 (PF14552) 646 (12.2%) View
DUF1904 (PF08921) 267 (5.0%) View
Tautomerase_3 (PF14832) 117 (2.2%) View
Total: 6 Total: 5290 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
CHMI CHMI
Tautomerase Tautomerase
MIF MIF
DUF1904 DUF1904

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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