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112  structures 4768  species 2  interactions 13122  sequences 46  architectures

Clan: MazG (CL0231)

Summary

all-alpha NTP pyrophosphohydrolase superfamily Add an annotation

This superfamily includes MazG, HisE and dimeric dUTPases (Not yet in Pfam) [1].

This clan contains 5 families and the total number of domains in the clan is 13122. The clan was built by A Bateman.

Literature references

  1. Moroz OV, Murzin AG, Makarova KS, Koonin EV, Wilson KS, Galperin MY; , J Mol Biol. 2005;347:243-255.: Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. PUBMED:15740738 EPMC:15740738

Members

This clan contains the following 5 member families:

DUF550 dUTPase_2 MazG MazG-like PRA-PH

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MazG (PF03819) 7328 (55.8%) View
PRA-PH (PF01503) 4463 (34.0%) View
dUTPase_2 (PF08761) 876 (6.7%) View
MazG-like (PF12643) 305 (2.3%) View
DUF550 (PF04447) 150 (1.1%) View
Total: 5 Total: 13122 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
PRA-PH PRA-PH
MazG MazG

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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