Summary
MtN3-like, vesicle-trafficking cargo-receptors
The clan forms a large and diverse family of proteins with seven transmembrane helices, common topology and, most likely, similar function. Their coding genes exist in all eukaryota and in several prokaryota. Some are responsible for metabolic diseases (cystinosis, congenital disorder of glycosylation), others are candidate genes for genetic disorders (cleft lip and palate, certain forms of cancer) or solute uptake and efflux (SWEETs) and many have not yet been assigned a function. Comparison with the properties of well-annotated clan members suggests that the proteins could be involved in protein trafficking and serve as cargo receptors in vesicle trafficking [3].
This clan contains 5 families and the total number of domains in the clan is 7738. The clan was built by J Mistry.
Literature references
- Gamas P, Niebel Fd, Lescure N, Cullimore J; , Mol Plant Microbe Interact 1996;9:233-242.: Use of a subtractive hybridization approach to identify new Medicago truncatula genes induced during root nodule development. PUBMED:8634476 EPMC:8634476
- Tagoh H, Kishi H, Muraguchi A; , Biochem Biophys Res Commun 1996;221:744-749.: Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors. PUBMED:8630032 EPMC:8630032
- Saudek V;, PLoS One. 2012;7:e30876.: Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors involved in vesicle trafficking. PUBMED:22363504 EPMC:22363504
Members
This clan contains the following 5 member families:
ER_lumen_recept LAB_N MPC MtN3_slv PQ-loopDomain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
Loading domain graphics...
Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
| Pfam family | Num. domains | Alignment |
|---|---|---|
| PQ-loop (PF04193) | 3702 (47.8%) | View |
| MtN3_slv (PF03083) | 2182 (28.2%) | View |
| MPC (PF03650) | 818 (10.6%) | View |
| ER_lumen_recept (PF00810) | 726 (9.4%) | View |
| LAB_N (PF07578) | 310 (4.0%) | View |
| Total: 5 | Total: 7738 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
Loading...
