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0  structures 3953  species 0  interactions 10451  sequences 55  architectures

Clan: NicO_HupE_DsbD (CL0549)

Summary

NicO/HupE/DsdD superfamily Add an annotation

This clan contains the nickel transpot family NicO [1-2] and the HupE/UreJ proteins, which may be involved in nickel binding. NicO and HupE contain a conserved GxxHxxxDH motif, which may bind to nickel.

This clan contains 6 families and the total number of domains in the clan is 10451. The clan was built by R Eberhardt.

Literature references

  1. Fu C, Javedan S, Moshiri F, Maier RJ; , Proc Natl Acad Sci U S A 1994;91:5099-5103.: Bacterial genes involved in incorporation of nickel into a hydrogenase enzyme. PUBMED:8197192 EPMC:8197192
  2. Mobley HL, Garner RM, Bauerfeind P; , Mol Microbiol 1995;16:97-109.: Helicobacter pylori nickel-transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions. PUBMED:7651142 EPMC:7651142

Members

This clan contains the following 6 member families:

DsbD DsbD_2 DUF2910 HupE_UreJ HupE_UreJ_2 NicO

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DsbD (PF02683) 5377 (51.4%) View
NicO (PF03824) 2471 (23.6%) View
DsbD_2 (PF13386) 1138 (10.9%) View
DUF2910 (PF11139) 566 (5.4%) View
HupE_UreJ (PF04955) 494 (4.7%) View
HupE_UreJ_2 (PF13795) 405 (3.9%) View
Total: 6 Total: 10451 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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