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83  structures 290  species 0  interactions 1853  sequences 23  architectures

Clan: Omega_toxin (CL0083)

Summary

Omega toxin-like Add an annotation

This clan contains a set of related small protein toxins and what appears to be the functionally distinct Albumin I domain. All members of this clan have a knottin-like fold. Additional information about this clan may be found from [1].

This clan contains 19 families and the total number of domains in the clan is 1853. The clan was built by RD Finn.

Literature references

  1. Gelly JC, Gracy J, Kaas Q, Le-Nguyen D, Heitz A, Chiche L; , Nucleic Acids Res 2004;32:D156-D159.: The KNOTTIN website and database: a new information system dedicated to the knottin scaffold. PUBMED:14681383 EPMC:14681383

Members

This clan contains the following 19 member families:

Agouti Albumin_I Conotoxin Mu-conotoxin Omega-toxin Tachystatin_B Toxin_11 Toxin_12 Toxin_16 Toxin_18 Toxin_21 Toxin_22 Toxin_23 Toxin_24 Toxin_27 Toxin_30 Toxin_7 Toxin_9 UPF0506

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Conotoxin (PF02950) 926 (50.0%) View
Agouti (PF05039) 278 (15.0%) View
Toxin_12 (PF07740) 254 (13.7%) View
Toxin_7 (PF05980) 91 (4.9%) View
Albumin_I (PF08027) 79 (4.3%) View
Toxin_22 (PF08092) 78 (4.2%) View
UPF0506 (PF11703) 31 (1.7%) View
Toxin_18 (PF08087) 30 (1.6%) View
Toxin_9 (PF02819) 29 (1.6%) View
Omega-toxin (PF06357) 17 (0.9%) View
Toxin_23 (PF08093) 8 (0.4%) View
Mu-conotoxin (PF05374) 7 (0.4%) View
Toxin_27 (PF08099) 5 (0.3%) View
Toxin_21 (PF08091) 5 (0.3%) View
Toxin_16 (PF07945) 4 (0.2%) View
Toxin_11 (PF07473) 4 (0.2%) View
Toxin_30 (PF08117) 3 (0.2%) View
Tachystatin_B (PF11478) 2 (0.1%) View
Toxin_24 (PF08094) 2 (0.1%) View
Total: 19 Total: 1853 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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