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59  structures 404  species 3  interactions 5383  sequences 399  architectures

Clan: PAN (CL0168)

Summary

PAN-like Add an annotation

PAN domains have significant functional versatility fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions [1]. These domains contain a hair-pin loop like structure, similar to knottins, but the pattern of disulphide bonds differs.

This clan contains 4 families and the total number of domains in the clan is 5383. The clan was built by RD Finn.

Literature references

  1. Tordai H, Banyai L, Patthy L; , FEBS Lett 1999;461:63-67.: The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins. PUBMED:10561497 EPMC:10561497

Members

This clan contains the following 4 member families:

PAN_1 PAN_2 PAN_3 PAN_4

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PAN_1 (PF00024) 2217 (41.2%) View
PAN_2 (PF08276) 1792 (33.3%) View
PAN_4 (PF14295) 1029 (19.1%) View
PAN_3 (PF08277) 345 (6.4%) View
Total: 4 Total: 5383 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
PAN_1 PAN_1
Kringle
Trypsin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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