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507  structures 6403  species 12  interactions 40855  sequences 138  architectures

Clan: PK_TIM (CL0151)

Summary

Pyruvate kinase-like TIM barrel superfamily Add an annotation

This superfamily consists of a number of TIM barrel domains found in enzymes such as pyruvate kinase, malate synthase and citrate lyase.

This clan contains 10 families and the total number of domains in the clan is 40855. The clan was built by A Bateman.

Members

This clan contains the following 10 member families:

C-C_Bond_Lyase HpcH_HpaI ICL Malate_synthase Pantoate_transf PEP-utilizers_C PEP_mutase PEPcase PEPcase_2 PK

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PEP-utilizers_C (PF02896) 9485 (23.2%) View
PK (PF00224) 7047 (17.2%) View
HpcH_HpaI (PF03328) 6388 (15.6%) View
ICL (PF00463) 4174 (10.2%) View
PEPcase (PF00311) 4128 (10.1%) View
Pantoate_transf (PF02548) 3509 (8.6%) View
PEP_mutase (PF13714) 2953 (7.2%) View
Malate_synthase (PF01274) 2722 (6.7%) View
C-C_Bond_Lyase (PF15617) 344 (0.8%) View
PEPcase_2 (PF14010) 105 (0.3%) View
Total: 10 Total: 40855 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 12 interactions for this clan. More...

Interacting families
A B
HpcH_HpaI HpcH_HpaI
PEPcase PEPcase
Pantoate_transf Pantoate_transf
PK PK
PEP-utilizers
PK_C
ICL ICL
PEP-utilizers_C PEP-utilizers
PPDK_N
PEP-utilizers_C
PEP-utilisers_N
Malate_synthase Malate_synthase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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