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24  structures 963  species 1  interaction 1328  sequences 15  architectures

Clan: PTH2 (CL0305)

Summary

Peptidyl-tRNA hydrolase II superfamily Add an annotation

This clan includes Peptidyl-tRNA hydrolase II as well as a large family of uncharacterised proteins called DUF2000. A structure for DUF2000 shows a similar structure to PTH2. It is not clear if the DUF2000 family are also Peptidyl-tRNA hydrolases. Both families contain a conserved positively charged residue close to the amino terminus that may be part of the active site.

This clan contains 2 families and the total number of domains in the clan is 1328. The clan was built by A Bateman.

Members

This clan contains the following 2 member families:

DUF2000 PTH2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PTH2 (PF01981) 1006 (75.8%) View
DUF2000 (PF09391) 322 (24.2%) View
Total: 2 Total: 1328 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
PTH2 PTH2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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