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1842  structures 2629  species 7  interactions 138509  sequences 629  architectures

Clan: Peptidase_AA (CL0129)

Summary

Peptidase clan AA Add an annotation

This clan contains aspartic peptidases, including the pepsins and retropepsins. These enzymes contains a catalytic dyad composed of two aspartates. In the retropepsins one is provided by each copy of a homodimeric protein, whereas in the pepsin-like peptidases these aspartates come from a single protein composed of two duplicated domains.

This clan contains 14 families and the total number of domains in the clan is 138509. The clan was built by A Bateman.

Members

This clan contains the following 14 member families:

Asp Asp_protease Asp_protease_2 DUF1758 gag-asp_proteas Peptidase_A2B Peptidase_A2E Peptidase_A3 RVP RVP_2 Spuma_A9PTase TAXi_C TAXi_N Zn_protease

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RVP (PF00077) 124336 (89.8%) View
Asp (PF00026) 4762 (3.4%) View
Asp_protease_2 (PF13650) 2359 (1.7%) View
TAXi_N (PF14543) 1620 (1.2%) View
TAXi_C (PF14541) 1552 (1.1%) View
RVP_2 (PF08284) 1125 (0.8%) View
Zn_protease (PF05618) 1019 (0.7%) View
gag-asp_proteas (PF13975) 832 (0.6%) View
Asp_protease (PF09668) 445 (0.3%) View
DUF1758 (PF05585) 313 (0.2%) View
Peptidase_A3 (PF02160) 102 (0.1%) View
Spuma_A9PTase (PF03539) 22 (0.0%) View
Peptidase_A2B (PF12384) 18 (0.0%) View
Peptidase_A2E (PF12382) 4 (0.0%) View
Total: 14 Total: 138509 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
RVP RVP
Zn_protease Zn_protease
Asp_protease Asp_protease
Asp Asp
Pepsin-I3
A1_Propeptide
Inhibitor_I34

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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