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224  structures 4739  species 14  interactions 30361  sequences 73  architectures

Clan: Peptidase_ME (CL0094)

Summary

LuxS/MPP-like metallohydrolase Add an annotation

All members of this clan are characterised by a HXXEH motif, which is is involved in zinc binding. Furthermore all members adopt an alpha and beta fold. More specifically, there us a four to six stranded antiparallel beta sheet surrounded by five helices. However, LuxS (PFAM:PF02664) is not a peptidase, although its hydrolytic mechanism of catalysis appears to be conserved [1].

This clan contains 4 families and the total number of domains in the clan is 30361. The clan was built by RD Finn.

Literature references

  1. Hilgers MT, Ludwig ML; , Proc Natl Acad Sci U S A 2001;98:11169-11174.: Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site. PUBMED:11553770 EPMC:11553770

Members

This clan contains the following 4 member families:

LuxS Peptidase_M16 Peptidase_M16_C Peptidase_M44

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_M16_C (PF05193) 16090 (53.0%) View
Peptidase_M16 (PF00675) 11461 (37.7%) View
LuxS (PF02664) 2731 (9.0%) View
Peptidase_M44 (PF03410) 79 (0.3%) View
Total: 4 Total: 30361 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 14 interactions for this clan. More...

Interacting families
A B
Peptidase_M16 UCR_14kD
UCR_TM
UcrQ
Peptidase_M16_C
Ubiq-Cytc-red_N
LuxS LuxS
Peptidase_M16_C Cytochrom_B_N
Peptidase_M16
UCR_14kD
UCR_TM
UcrQ
Peptidase_M16_C
UCR_6-4kD
Ubiq-Cytc-red_N

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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