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47  structures 5096  species 4  interactions 20383  sequences 75  architectures

Clan: Peptidase_SF (CL0299)

Summary

Peptidase clan SF Add an annotation

This clan includes the peptidase S24 and S26 families. These families adopt a mainly beta fold. Members of the family S24 have an additional C-terminal domain containing a bundle of three helices presumably important for binding DNA.

This clan contains 2 families and the total number of domains in the clan is 20383. The clan was built by J Mistry and N Rawlings.

Literature references

  1. Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC; , Cell. 2001;106:585-594.: Crystal structure of LexA: a conformational switch for regulation of self-cleavage. PUBMED:11551506 EPMC:11551506
  2. Paetzel M, Chernaia M, Strynadka N, Tschantz W, Cao G, Dalbey RE, James MN; , Proteins. 1995;23:122-125.: Crystallization of a soluble, catalytically active form of Escherichia coli leader peptidase. PUBMED:8539246 EPMC:8539246

Members

This clan contains the following 2 member families:

Peptidase_S24 Peptidase_S26

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_S24 (PF00717) 17337 (85.1%) View
Peptidase_S26 (PF10502) 3046 (14.9%) View
Total: 2 Total: 20383 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
Peptidase_S26 Peptidase_S24
Peptidase_S26
Peptidase_S24 Peptidase_S24
Peptidase_S26

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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