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852  structures 12549  species 6  interactions 220781  sequences 1801  architectures

Clan: RdRP (CL0027)

Summary

RNA dependent RNA polymerase Add an annotation

This clan represents the replicative RNA dependent RNA polymerase. from a variety of RNA viruses [1].

This clan contains 8 families and the total number of domains in the clan is 220781. The clan was built by A Bateman.

Literature references

  1. Koonin EV; , J Gen Virol 1991;72:2197-2206.: The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. PUBMED:1895057 EPMC:1895057

Members

This clan contains the following 8 member families:

Flavi_NS5 Mitovir_RNA_pol RdRP_1 RdRP_2 RdRP_3 RdRP_4 RVT_1 RVT_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RVT_1 (PF00078) 172360 (78.1%) View
RdRP_3 (PF00998) 17276 (7.8%) View
RdRP_1 (PF00680) 14992 (6.8%) View
RVT_2 (PF07727) 7027 (3.2%) View
Flavi_NS5 (PF00972) 5252 (2.4%) View
RdRP_2 (PF00978) 2606 (1.2%) View
RdRP_4 (PF02123) 1146 (0.5%) View
Mitovir_RNA_pol (PF05919) 122 (0.1%) View
Total: 8 Total: 220781 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 6 interactions for this clan. More...

Interacting families
A B
RdRP_3 RdRP_3
RdRP_1 Peptidase_C3
RdRP_1
RVT_1 RVT_1
RVT_connect
RVT_thumb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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