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25  structures 3938  species 1  interaction 11895  sequences 62  architectures

Clan: Rep (CL0169)

Summary

Rep-like domain Add an annotation

This clan includes replication proteins for viruses and plasmids. This domain is known to bind DNA. The members of this clan have three motifs. The central HXH is conserved in most families in the clan.

This clan contains 9 families and the total number of domains in the clan is 11895. The clan was built by A Bateman.

Members

This clan contains the following 9 member families:

DUF1424 Gemini_AL1 Mob_Pre MobA_MobL Phage_GPA Relaxase Rep_1 T_Ag_DNA_bind Viral_Rep

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Gemini_AL1 (PF00799) 3067 (25.8%) View
Relaxase (PF03432) 2990 (25.1%) View
Viral_Rep (PF02407) 1309 (11.0%) View
MobA_MobL (PF03389) 1275 (10.7%) View
Phage_GPA (PF05840) 1036 (8.7%) View
Mob_Pre (PF01076) 1003 (8.4%) View
Rep_1 (PF01446) 775 (6.5%) View
T_Ag_DNA_bind (PF02217) 427 (3.6%) View
DUF1424 (PF07232) 13 (0.1%) View
Total: 9 Total: 11895 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
T_Ag_DNA_bind T_Ag_DNA_bind

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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