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27  structures 1412  species 1  interaction 7537  sequences 1046  architectures

Clan: STIR (CL0173)

Summary

STIR superfamily Add an annotation

Both members of this clan are thought to be involved in TOLL/IL1R-like pathways, by mediating protein-protein interactions between pathway components. The N-termini of SEFIR and TIR domains are similar, but the domains are more divergent towards the C-terminus [1].

This clan contains 4 families and the total number of domains in the clan is 7537. The clan was built by M Fenech.

Literature references

  1. Novatchkova M, Leibbrandt A, Werzowa J, Neubuser A, Eisenhaber F; , Trends Biochem Sci 2003;28:226-229.: The STIR-domain superfamily in signal transduction, development and immunity. PUBMED:12765832 EPMC:12765832

Members

This clan contains the following 4 member families:

DUF1863 SEFIR TIR TIR_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TIR (PF01582) 4612 (61.2%) View
TIR_2 (PF13676) 2056 (27.3%) View
SEFIR (PF08357) 480 (6.4%) View
DUF1863 (PF08937) 389 (5.2%) View
Total: 4 Total: 7537 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
TIR TIR

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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