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1  structure 3179  species 0  interactions 4912  sequences 12  architectures

Clan: T3SS-hook (CL0424)

Summary

Type III secretion system-derived superfamily, hook-related Add an annotation

There is homology between the proteins forming the flagellar system and those involved in translocation of effector proteins at host-infection. Both systems, in Gram-negative bacteria, are Sec-independent but ATPase-dependent. There are up to 9 proteins that are homologous between the two systems. It is not clear, however, why HpaP proteins, which are essentially suppressants of HrpB2, an essential pathogenicity factor, should also be homologous to any of these families.

This clan contains 3 families and the total number of domains in the clan is 4912. The clan was built by P Coggill.

Literature references

  1. Desvaux M, Hebraud M, Henderson IR, Pallen MJ;, Trends Microbiol. 2006;14:157-160.: Type III secretion: what's in a name?. PUBMED:16533600 EPMC:16533600

Members

This clan contains the following 3 member families:

DUF721 Flg_hook HpaP

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Flg_hook (PF02120) 2733 (55.6%) View
DUF721 (PF05258) 2098 (42.7%) View
HpaP (PF09483) 81 (1.6%) View
Total: 3 Total: 4912 Clan alignment
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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