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947  structures 6771  species 72  interactions 404043  sequences 20914  architectures

Clan: TPR (CL0020)

Summary

Tetratrico peptide repeat superfamily Add an annotation

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

This clan contains 117 families and the total number of domains in the clan is 404043. The clan was built by DJ Studholme.

Literature references

  1. Lamb JR, Tugendreich S, Hieter P; , Trends Biochem Sci 1995;20:257-259.: Tetratrico peptide repeat interactions: to TPR or not to TPR? PUBMED:7667876 EPMC:7667876
  2. Das AK, Cohen PW, Barford D; , EMBO J 1998;17:1192-1199.: The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. PUBMED:9482716 EPMC:9482716
  3. Pallen MJ, Francis MS, Futterer K; , FEMS Microbiol Lett 2003;223:53-60.: Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators. PUBMED:12799000 EPMC:12799000
  4. Rispal D, Henri J, van Tilbeurgh H, Graille M, Seraphin B;, RNA. 2011; [Epub ahead of print]: Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe. PUBMED:21610214 EPMC:21610214

Members

This clan contains the following 117 member families:

Adaptin_N Alkyl_sulf_dimr Apc3 Apc5 API5 Arm Arm_2 Avirulence BTAD CAS_CSE1 ChAPs CLASP_N Clathrin Clathrin-link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load CRM1_C Cse1 DNA_alkylation Drf_FH3 Drf_GBD DUF1822 DUF2225 DUF3385 DUF3458 DUF3808 DUF3856 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4 HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HemY_N IBB IBN_N IFRD KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 NARP1 Neurochondrin Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PPP5 PPR PPR_1 PPR_2 PPR_3 Proteasom_PSMB PUF Rab5-bind Rapsyn_N RPN7 Sel1 SHNi-TPR SNAP SPO22 ST7 Suf SusD SusD-like SusD-like_2 SusD-like_3 Tcf25 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 Xpo1 YfiO

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TPR_11 (PF13414) 62040 (15.4%) View
Sel1 (PF08238) 40768 (10.1%) View
PPR_2 (PF13041) 33080 (8.2%) View
PPR (PF01535) 31410 (7.8%) View
TPR_12 (PF13424) 22703 (5.6%) View
TPR_1 (PF00515) 18473 (4.6%) View
TPR_2 (PF07719) 18395 (4.6%) View
Arm (PF00514) 12724 (3.1%) View
HEAT_2 (PF13646) 11825 (2.9%) View
TPR_16 (PF13432) 9987 (2.5%) View
TPR_19 (PF14559) 8943 (2.2%) View
TPR_8 (PF13181) 8299 (2.1%) View
PUF (PF00806) 6866 (1.7%) View
SusD (PF07980) 6618 (1.6%) View
SusD-like_3 (PF14322) 6539 (1.6%) View
TPR_6 (PF13174) 6355 (1.6%) View
PPR_3 (PF13812) 5769 (1.4%) View
TPR_10 (PF13374) 5651 (1.4%) View
TPR_9 (PF13371) 4976 (1.2%) View
Clathrin (PF00637) 4251 (1.1%) View
Adaptin_N (PF01602) 3862 (1.0%) View
PPR_1 (PF12854) 3378 (0.8%) View
IBN_N (PF03810) 2930 (0.7%) View
YfiO (PF13525) 2784 (0.7%) View
TPR_7 (PF13176) 2738 (0.7%) View
MIF4G (PF02854) 2682 (0.7%) View
DNA_alkylation (PF08713) 2486 (0.6%) View
BTAD (PF03704) 2191 (0.5%) View
HEAT (PF02985) 1878 (0.5%) View
TPR_20 (PF14561) 1831 (0.5%) View
HEAT_EZ (PF13513) 1731 (0.4%) View
MA3 (PF02847) 1720 (0.4%) View
DUF3458 (PF11940) 1678 (0.4%) View
TPR_21 (PF09976) 1664 (0.4%) View
Apc3 (PF12895) 1548 (0.4%) View
HemY_N (PF07219) 1471 (0.4%) View
Xpo1 (PF08389) 1456 (0.4%) View
PC_rep (PF01851) 1407 (0.3%) View
Drf_GBD (PF06371) 1367 (0.3%) View
PI3Ka (PF00613) 1353 (0.3%) View
CLASP_N (PF12348) 1343 (0.3%) View
FAT (PF02259) 1294 (0.3%) View
W2 (PF02020) 1188 (0.3%) View
TPR_3 (PF07720) 1102 (0.3%) View
Drf_FH3 (PF06367) 1087 (0.3%) View
Vitellogenin_N (PF01347) 1005 (0.2%) View
TPR_15 (PF13429) 995 (0.2%) View
Alkyl_sulf_dimr (PF14863) 988 (0.2%) View
IBB (PF01749) 914 (0.2%) View
SNAP (PF14938) 864 (0.2%) View
Avirulence (PF03377) 801 (0.2%) View
TPR_17 (PF13431) 768 (0.2%) View
TPR_14 (PF13428) 700 (0.2%) View
EST1_DNA_bind (PF10373) 696 (0.2%) View
SusD-like (PF12741) 684 (0.2%) View
RPN7 (PF10602) 673 (0.2%) View
SusD-like_2 (PF12771) 655 (0.2%) View
Cse1 (PF08506) 650 (0.2%) View
Leuk-A4-hydro_C (PF09127) 628 (0.2%) View
continued
Pfam family Num. domains Alignment
Suf (PF05843) 583 (0.1%) View
Clathrin_propel (PF01394) 581 (0.1%) View
Cnd1 (PF12717) 571 (0.1%) View
DUF3808 (PF10300) 568 (0.1%) View
NARP1 (PF12569) 545 (0.1%) View
Rab5-bind (PF09311) 544 (0.1%) View
Mo25 (PF08569) 518 (0.1%) View
CRM1_C (PF08767) 475 (0.1%) View
TPR_4 (PF07721) 472 (0.1%) View
Clathrin-link (PF09268) 470 (0.1%) View
Paf67 (PF10255) 467 (0.1%) View
Apc5 (PF12862) 461 (0.1%) View
V-ATPase_H_N (PF03224) 456 (0.1%) View
PPP5 (PF08321) 434 (0.1%) View
Coatomer_E (PF04733) 430 (0.1%) View
TPR_5 (PF12688) 427 (0.1%) View
Cohesin_HEAT (PF12765) 424 (0.1%) View
HAT (PF02184) 422 (0.1%) View
ST7 (PF04184) 405 (0.1%) View
IFRD (PF05004) 396 (0.1%) View
Arm_2 (PF04826) 392 (0.1%) View
DUF3385 (PF11865) 388 (0.1%) View
V-ATPase_H_C (PF11698) 388 (0.1%) View
CAS_CSE1 (PF03378) 387 (0.1%) View
Vac14_Fab1_bd (PF12755) 386 (0.1%) View
Foie-gras_1 (PF11817) 379 (0.1%) View
GUN4 (PF05419) 375 (0.1%) View
Vps39_1 (PF10366) 369 (0.1%) View
Fis1_TPR_C (PF14853) 363 (0.1%) View
Tcf25 (PF04910) 359 (0.1%) View
HEAT_PBS (PF03130) 340 (0.1%) View
ParcG (PF10274) 338 (0.1%) View
Cnd3 (PF12719) 330 (0.1%) View
MIF4G_like (PF09088) 328 (0.1%) View
ChAPs (PF09295) 327 (0.1%) View
SHNi-TPR (PF10516) 326 (0.1%) View
MIF4G_like_2 (PF09090) 319 (0.1%) View
Fis1_TPR_N (PF14852) 299 (0.1%) View
KAP (PF05804) 298 (0.1%) View
MMS19_C (PF12460) 284 (0.1%) View
Upf2 (PF04050) 283 (0.1%) View
Cohesin_load (PF10345) 268 (0.1%) View
DUF2225 (PF09986) 252 (0.1%) View
Proteasom_PSMB (PF10508) 249 (0.1%) View
Neurochondrin (PF05536) 217 (0.1%) View
LRV (PF01816) 206 (0.1%) View
API5 (PF05918) 205 (0.1%) View
SPO22 (PF08631) 164 (0.0%) View
MRP-S27 (PF10037) 150 (0.0%) View
DUF1822 (PF08852) 120 (0.0%) View
TOM20_plant (PF06552) 100 (0.0%) View
Rapsyn_N (PF10579) 91 (0.0%) View
TPR_18 (PF13512) 80 (0.0%) View
LRV_FeS (PF05484) 74 (0.0%) View
Nro1 (PF12753) 53 (0.0%) View
PHAT (PF09246) 24 (0.0%) View
DUF3856 (PF12968) 11 (0.0%) View
NSF (PF02071) 10 (0.0%) View
Total: 117 Total: 404043 Clan alignment
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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