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17  structures 2250  species 1  interaction 7994  sequences 93  architectures

Clan: TolA-TonB-Cterm (CL0428)

Summary

TolA/TonB C-terminal Add an annotation

This clan contains the TolA and TonB C terminal domains. These domains adopt a structure containing anti-parallel beta sheets with some alpha helical regions. The TolA family contains an extra N-terminal helix over the common fold, and the TonB is an isolated domain that can form different segment-swapped dimers depending on the fragment length [1].

This clan contains 3 families and the total number of domains in the clan is 7994. The clan was built by J Mistry and RD Finn.

Literature references

  1. Sean Peacock R, Weljie AM, Peter Howard S, Price FD, Vogel HJ;, J Mol Biol. 2005;345:1185-1197.: The solution structure of the C-terminal domain of TonB and interaction studies with TonB box peptides. PUBMED:15644214 EPMC:15644214

Members

This clan contains the following 3 member families:

TolA TonB_2 TonB_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TonB_C (PF03544) 5753 (72.0%) View
TonB_2 (PF13103) 1325 (16.6%) View
TolA (PF06519) 916 (11.5%) View
Total: 3 Total: 7994 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
TonB_C TonB_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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