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294  structures 870  species 11  interactions 12063  sequences 238  architectures

Clan: UBC (CL0208)

Summary

Ubiquitin conjugating enzyme like superfamily Add an annotation

This superfamily includes a diverse set of proteins that bind to ubiquitin [1].

This clan contains 9 families and the total number of domains in the clan is 12063. The clan was built by A Bateman.

Literature references

  1. Andersen KM, Hofmann K, Hartmann-Petersen R; , Essays Biochem 2005;41:49-67.: Ubiquitin-binding proteins: similar, but different. PUBMED:16250897 EPMC:16250897

Members

This clan contains the following 9 member families:

Prok-E2_A Prok-E2_B Prok-E2_C Prok-E2_D Prok-E2_E RWD UEV UFC1 UQ_con

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UQ_con (PF00179) 9194 (76.2%) View
RWD (PF05773) 1878 (15.6%) View
UEV (PF05743) 474 (3.9%) View
UFC1 (PF08694) 167 (1.4%) View
Prok-E2_D (PF14460) 151 (1.3%) View
Prok-E2_B (PF14461) 108 (0.9%) View
Prok-E2_A (PF14457) 50 (0.4%) View
Prok-E2_E (PF14462) 36 (0.3%) View
Prok-E2_C (PF14459) 5 (0.0%) View
Total: 9 Total: 12063 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 11 interactions for this clan. More...

Interacting families
A B
UQ_con zf-C3HC4
UQ_con
ubiquitin
UBA
HECT
ThiF
Cbl_N2
U-box
E2_bind
UEV UEV
UFC1 UFC1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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