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5  structures 443  species 0  interactions 6439  sequences 215  architectures

Clan: WRKY-GCM1 (CL0274)

Summary

WRKY-GCM1 superfamily Add an annotation

WRKY and GCM1 are metal chelating DNA-binding domains (DBD) which share a four stranded fold [1]. We present evidence that they share a stabilising core, which suggests a possible origin from a BED finger-like intermediate that was in turn ultimately derived from a C2H2 Zn-finger domain [1].

This clan contains 6 families and the total number of domains in the clan is 6439. The clan was built by A Bateman.

Literature references

  1. Babu MM, Iyer LM, Balaji S, Aravind L; , Nucleic Acids Res. 2006; [Epub ahead of print]: The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons. PUBMED:17130173 EPMC:17130173

Members

This clan contains the following 6 member families:

AFT DBD_Tnp_Mut FAR1 FLYWCH GCM WRKY

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
WRKY (PF03106) 3051 (47.4%) View
FLYWCH (PF04500) 1130 (17.5%) View
FAR1 (PF03101) 1076 (16.7%) View
DBD_Tnp_Mut (PF03108) 954 (14.8%) View
GCM (PF03615) 146 (2.3%) View
AFT (PF08731) 82 (1.3%) View
Total: 6 Total: 6439 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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