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13  structures 723  species 1  interaction 1328  sequences 4  architectures

Clan: YycI_YycH (CL0285)

Summary

YycI/YycH superfamily Add an annotation

Both, YycH and YycI are always found in a pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Structural studies show that these two protein families share two related domains.

This clan contains 2 families and the total number of domains in the clan is 1328. The clan was built by A Bateman.

Literature references

  1. Santelli E, Liddington RC, Mohan MA, Hoch JA, Szurmant H; , J Bacteriol. 2007;189:3290-3295.: The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins. PUBMED:17307848 EPMC:17307848

Members

This clan contains the following 2 member families:

YycH YycI

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
YycI (PF09648) 732 (55.1%) View
YycH (PF07435) 596 (44.9%) View
Total: 2 Total: 1328 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
YycI YycI

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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