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44  structures 4454  species 1  interaction 15593  sequences 106  architectures

Clan: pap2 (CL0525)

Summary

Acid phosphatase/Vanadium-dependent haloperoxidase Add an annotation

The PAP2 superfamily is characterised by being mult-helical, with the core consisting of a 5-helical bundle. Normally the family will bind cofactor at the beginning of the third helix. The superfamily includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.

This clan contains 3 families and the total number of domains in the clan is 15593. The clan was built by P Coggill.

Literature references

  1. Stukey J, Carman GM; , Protein Sci 1997;6:469-472.: Identification of a novel phosphatase sequence motif. PUBMED:9041652 EPMC:9041652
  2. Neuwald AF; , Protein Sci 1997;6:1764-1767.: An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases. PUBMED:9260289 EPMC:9260289
  3. Messerschmidt A, Wever R; , Proc Natl Acad Sci U S A 1996;93:392-396.: X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis. PUBMED:8552646 EPMC:8552646

Members

This clan contains the following 3 member families:

PAP2 PAP2_3 PAP2_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PAP2 (PF01569) 14398 (92.3%) View
PAP2_3 (PF14378) 684 (4.4%) View
PAP2_C (PF14360) 511 (3.3%) View
Total: 3 Total: 15593 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
PAP2 PAP2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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