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0  structures 51  species 0  interactions 1580  sequences 10  architectures

Family: 7tm_7 (PF08395)

Summary: 7tm Chemosensory receptor

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

7tm Chemosensory receptor Provide feedback

This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [1,2].

Literature references

  1. Robertson HM, Warr CG, Carlson JR; , Proc Natl Acad Sci U S A 2003;100:14537-14542.: Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. PUBMED:14608037 EPMC:14608037

  2. Hill CA, Fox AN, Pitts RJ, Kent LB, Tan PL, Chrystal MA, Cravchik A, Collins FH, Robertson HM, Zwiebel LJ; , Science 2002;298:176-178.: G protein-coupled receptors in Anopheles gambiae. PUBMED:12364795 EPMC:12364795


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR013604

This family includes a number of gustatory and odorant receptors mainly from insect species such as Anopheles gambiae (African malaria mosquito) and Drosophila melanogaster (Fruit fly). They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [PUBMED:14608037, PUBMED:12364795].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Chemosens_recp (CL0176), which contains the following 4 members:

7tm_6 7tm_7 DUF267 Trehalose_recp

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(78)
Full
(1580)
Representative proteomes NCBI
(2288)
Meta
(0)
RP15
(345)
RP35
(411)
RP55
(732)
RP75
(884)
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PP/heatmap 1 View  View  View  View  View     
Pfam viewer View  View             

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(78)
Full
(1580)
Representative proteomes NCBI
(2288)
Meta
(0)
RP15
(345)
RP35
(411)
RP55
(732)
RP75
(884)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(78)
Full
(1580)
Representative proteomes NCBI
(2288)
Meta
(0)
RP15
(345)
RP35
(411)
RP55
(732)
RP75
(884)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Robertson H
Previous IDs: none
Type: Family
Author: Robertson H, Finn R, Fenech M
Number in seed: 78
Number in full: 1580
Average length of the domain: 315.20 aa
Average identity of full alignment: 12 %
Average coverage of the sequence by the domain: 89.70 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.6 26.6
Trusted cut-off 26.6 26.6
Noise cut-off 26.5 26.5
Model length: 372
Family (HMM) version: 7
Download: download the raw HMM for this family

Species distribution

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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