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0  structures 89  species 0  interactions 186  sequences 8  architectures

Family: DBC1 (PF14443)

Summary: DBC1

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

DBC1 Provide feedback

DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain [1]. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction [1].

Literature references

  1. Anantharaman V, Aravind L;, Cell Cycle. 2008;7:1467-1472.: Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites. PUBMED:18418069 EPMC:18418069


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR025954

Deleted in breast cancer 1 (DBC1) and its paralogue cell division cycle and apoptosis regulator protein 1 (CARP1) are large multi-domain proteins, with a nuclear or perinuclear localisation, and a role in promoting apoptosis upon processing by caspases [PUBMED:18418069]. This entry represents the central conserved globular domain present in DBC1 and homologues, and is a catalytically inactive version of the Nudix hydrolase (MutT) domain [PUBMED:18418069]. It may have a role in binding NAD metabolites, such as ADP-ribose.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan NUDIX (CL0261), which contains the following 5 members:

DBC1 NUDIX NUDIX-like NUDIX_2 NUDIX_4

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(13)
Full
(186)
Representative proteomes NCBI
(182)
Meta
(0)
RP15
(32)
RP35
(49)
RP55
(73)
RP75
(108)
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PP/heatmap 1 View  View  View  View  View     
Pfam viewer View  View             

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(13)
Full
(186)
Representative proteomes NCBI
(182)
Meta
(0)
RP15
(32)
RP35
(49)
RP55
(73)
RP75
(108)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(13)
Full
(186)
Representative proteomes NCBI
(182)
Meta
(0)
RP15
(32)
RP35
(49)
RP55
(73)
RP75
(108)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Manual
Previous IDs: none
Type: Domain
Author: Anantharaman V
Number in seed: 13
Number in full: 186
Average length of the domain: 122.50 aa
Average identity of full alignment: 51 %
Average coverage of the sequence by the domain: 12.57 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 26.3 26.4
Noise cut-off 22.7 21.5
Model length: 127
Family (HMM) version: 1
Download: download the raw HMM for this family

Species distribution

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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