Summary
MviN-like protein
Deletion of the mviN virulence gene in Salmonella enterica serovar. Typhimurium greatly reduces virulence in a mouse model of typhoid-like disease [1]. Open reading frames encoding homologues of MviN have since been identified in a variety of bacteria [2] including pathogens and non-pathogens and plant-symbionts. In the nitrogen-fixing symbiont Rhizobium tropici, mviN is required for motility. The MviM protein is predicted to be membrane-associated.
Literature references
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Carsiotis M, Stocker BA, Weinstein DL, O'Brien AD; , Infect Immun 1989;57:3276-3280.: A Salmonella typhimurium virulence gene linked to flg. PUBMED:2680969
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Rudnick PA, Arcondeguy T, Kennedy CK, Kahn D; , J Bacteriol 2001;183:2682-2685.: glnD and mviN are genes of an essential operon in Sinorhizobium meliloti. PUBMED:11274131
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O'Connell KP, Raffel SJ, Saville BJ, Handelsman J; , Microbiology 1998;144:2607-2617.: Mutants of Rhizobium tropici strain CIAT899 that do not induce chlorosis in plants. PUBMED:9782510
InterPro entry IPR004268
This entry represents MviN, a family of integral membrane proteins predicted to have ten or more transmembrane regions. Although frequently listed as a virulence protein, it is not restricted to pathogens and it is an essential protein in Sinorhizobium meliloti. In a number of species its gene is adjacent to that of the uridylyltransferase GlnD, the signal-transducing enzyme that performs the key modification to the nitrogen regulatory protein PII PUBMED:11274131.
Disruption of the MviN open reading frame results in flagellar structures that contain only the basal body and hook complex that lack the flagellum; suggesting that MviN might be involved in flagellin export or assembly PUBMED:8200538. Genome comparison studies led to MviN being predicted to be a peptidoglycan lipid II flippase though currently there is no direct evidence to support this annotation PUBMED:18832143.
Clan
This family is a member of clan MviN_MATE (CL0222), which contains the following 4 members:
MatE MVIN Polysacc_synt Rft-1External database links
| PANDIT: | PF03023 |
| SYSTERS: | MVIN |
| Transporter classification: | 2.A.66 |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Alignments
There are various ways to view or download the sequence alignments that we store. You can use a sequence viewer to look at either the seed or full alignment for the family, or you can look at a plain text version of the sequence in a variety of different formats. More...
View options
Formatting options
Download options
Very large alignments can often cause problems for the formatting tool above. If you find that downloading or viewing a large alignment is problematic, you can also download a gzip-compressed, Stockholm-format file containing the seed or full alignment for this family.
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
The main seed and full alignments are generated using sequences from the UniProt sequence database. However, we also generate alignments using sequences from the NCBI sequence database and the "metaseq" metagenomics dataset.
You can view alignments from these two additional datasets using the form above, or you can download alignments of NCBI or metagenomics sequences, as gzip-compressed files.
External links
MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER2.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed or full alignments.
Note: You can also download the data files for the seed, full, NCBI or metagenomics trees.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
| Seed source: | Pfam-B_1348 (release 6.4) |
| Previous IDs: | none |
| Type: | Family |
| Author: | Griffiths-Jones SR, Studholme DJ |
| Number in seed: | 15 |
| Number in full: | 1260 |
| Average length of the domain: | 440.70 aa |
| Average identity of full alignment: | 27 % |
| Average coverage of the sequence by the domain: | 81.63 % |
HMM information
| HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 9421015 -E 1000 HMM pfamseq
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| Model details: |
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| Model length: | 452 | ||||||||||||
| Family (HMM) version: | 7 | ||||||||||||
| Download: | download the raw HMM for this family |
Species distribution
Tree controls
HideThe tree shows the occurrence of this domain across different species. More...
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