Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 651  species 0  interactions 2182  sequences 19  architectures

Family: MtN3_slv (PF03083)

Summary: Sugar efflux transporter for intercellular exchange

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Sugar efflux transporter for intercellular exchange Provide feedback

This family includes proteins such as drosophila saliva [1] MtN3 involved in root nodule development [3] and a protein involved in activation and expression of recombination activation genes (RAGs) [2]. Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organisims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologues are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter [4].

Literature references

  1. Artero RD, Terol-Alcayde J, Paricio N, Ring J, Bargues M, Torres A, Perez-Alonso M; , Mech Dev 1998;75:159-162.: saliva, a new Drosophila gene expressed in the embryonic salivary glands with homologues in plants and vertebrates. PUBMED:9739134 EPMC:9739134

  2. Tagoh H, Kishi H, Muraguchi A; , Biochem Biophys Res Commun 1996;221:744-749.: Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors. PUBMED:8630032 EPMC:8630032

  3. Gamas P, Niebel Fd, Lescure N, Cullimore J; , Mol Plant Microbe Interact 1996;9:233-242.: Use of a subtractive hybridization approach to identify new Medicago truncatula genes induced during root nodule development. PUBMED:8634476 EPMC:8634476

  4. Chen LQ, Hou BH, Lalonde S, Takanaga H, Hartung ML, Qu XQ, Guo WJ, Kim JG, Underwood W, Chaudhuri B, Chermak D, Antony G, White FF, Somerville SC, Mudgett MB, Frommer WB;, Nature. 2010;468:527-532.: Sugar transporters for intercellular exchange and nutrition of pathogens. PUBMED:21107422 EPMC:21107422


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004316

This family contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organisms it mediates glucose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologues are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter [PUBMED:21107422].

The founding member of the SWEET family, MtN3, was identified as a nodulin-specific EST in the legume Medicago truncatula [PUBMED:8634476]. Another protein in this family may be involved in activation and expression of recombination activation genes (RAGs) [PUBMED:8630032].

This family contains a region of two transmembrane helices that is found in two copies in most members of the family.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Pfam Clan

This family is a member of clan MtN3-like (CL0141), which contains the following 5 members:

ER_lumen_recept LAB_N MPC MtN3_slv PQ-loop

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(25)
Full
(2182)
Representative proteomes NCBI
(2047)
Meta
(467)
RP15
(350)
RP35
(759)
RP55
(1105)
RP75
(1265)
Jalview View  View  View  View  View  View  View  View 
HTML View  View  View  View  View  View     
PP/heatmap 1 View  View  View  View  View     
Pfam viewer View  View             

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(25)
Full
(2182)
Representative proteomes NCBI
(2047)
Meta
(467)
RP15
(350)
RP35
(759)
RP55
(1105)
RP75
(1265)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(25)
Full
(2182)
Representative proteomes NCBI
(2047)
Meta
(467)
RP15
(350)
RP35
(759)
RP55
(1105)
RP75
(1265)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_623 (release 6.4)
Previous IDs: none
Type: Family
Author: Bateman A
Number in seed: 25
Number in full: 2182
Average length of the domain: 83.20 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 68.44 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.2 21.2
Trusted cut-off 21.2 21.2
Noise cut-off 21.1 21.1
Model length: 87
Family (HMM) version: 11
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Show

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.