Summary: NOT2 / NOT3 / NOT5 family
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NOT2 / NOT3 / NOT5 family Provide feedback
NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.
Collart MA, Struhl K; , Genes Dev 1994;8:525-537.: NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. PUBMED:7926748 EPMC:7926748
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007282NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.
|Cellular component||nucleus (GO:0005634)|
|Biological process||regulation of transcription, DNA-dependent (GO:0006355)|
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Curation and family details
|Seed source:||Pfam-B_2131 (release 7.3)|
|Number in seed:||66|
|Number in full:||799|
|Average length of the domain:||125.90 aa|
|Average identity of full alignment:||31 %|
|Average coverage of the sequence by the domain:||23.73 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||13|
|Download:||download the raw HMM for this family|
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