Summary: cAMP-regulated phosphoprotein/endosulfine conserved region
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cAMP-regulated phosphoprotein/endosulfine conserved region Provide feedback
Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein [1,2].
Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC; , J Neurochem 2001;77:229-238.: ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. PUBMED:11279279 EPMC:11279279
Bataille D, Heron L, Virsolvy A, Peyrollier K, LeCam A, Gros L, Blache P; , Cell Mol Life Sci 1999;56:78-84.: alpha-Endosulfine, a new entity in the control of insulin secretion. PUBMED:11213264 EPMC:11213264
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR006760
This endosulphine family includes cAMP-regulated phosphoprotein 19 (ARPP-19), alpha endosulphine and protein Igo1.
No function has yet been assigned to ARPP-19 [PUBMED:11279279]. Endosulphine is the endogenous ligand for the ATP-dependent potassium channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism [PUBMED:11213264]. Igo1 is required for initiation of G0 program. In the absence of stimulatory signals, cells may enter into a reversible quiescence (or G0) state that is typically characterised by low metabolic activity, including low rates of protein synthesis and transcription. Igo proteins associate with the mRNA decapping activator Dhh1, sheltering newly expressed mRNAs from degradation via the 5'-3' mRNA decay pathway, and thereby enabling their proper translation during initiation of the G0 program [PUBMED:20471941].
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Curation and family details
|Seed source:||Pfam-B_4454 (release 7.5)|
|Author:||Waterfield DI, Finn RD|
|Number in seed:||12|
|Number in full:||485|
|Average length of the domain:||86.40 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||63.05 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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