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0  structures 115  species 0  interactions 214  sequences 7  architectures

Family: Dicty_CAR (PF05462)

Summary: Slime mold cyclic AMP receptor

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This is the Wikipedia entry entitled "Cyclic AMP receptors". More...

Cyclic AMP receptors Edit Wikipedia article

Slime mold cyclic AMP receptor
Identifiers
Symbol Dicty_CAR
Pfam PF05462
Pfam clan CL0192
InterPro IPR000848
PROSITE PDOC00691

Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. These receptors control development in Dictyostelium discoideum.

The cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes.[1][2][3] The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.

[edit] See also

[edit] References

  1. ^ Devreotes PN, Kimmel AR, Johnson RL, Klein PS, Sun TJ, Saxe III CL (1988). "A chemoattractant receptor controls development in Dictyostelium discoideum". Science 241 (4872): 1467–1472. doi:10.1126/science.3047871. PMID 3047871.
  2. ^ Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR, Saxe III CL (1993). "CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum". Genes Dev. 7 (2): 262–272. doi:10.1101/gad.7.2.262. PMID 8436297.
  3. ^ Devreotes PN, Kimmel AR, Johnson RL, Gollop R, Saxe III CL (1993). "Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development". Genes Dev. 7 (2): 273–282. doi:10.1101/gad.7.2.273. PMID 8382181.


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Slime mold cyclic AMP receptor Provide feedback

This family consists of cyclic AMP receptor (CAR) proteins from slime molds. CAR proteins are responsible for controlling development in Dictyostelium discoideum [1,2,3,4].

Literature references

  1. Johnson RL, Saxe CL 3rd, Gollop R, Kimmel AR, Devreotes PN; , Genes Dev 1993;7:273-282.: Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development. PUBMED:8382181 EPMC:8382181

  2. Louis JM, Ginsburg GT, Kimmel AR; , Genes Dev 1994;8:2086-2096.: The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium. PUBMED:7958880 EPMC:7958880

  3. Klein PS, Sun TJ, Saxe CL 3rd, Kimmel AR, Johnson RL, Devreotes PN; , Science 1988;241:1467-1472.: A chemoattractant receptor controls development in Dictyostelium discoideum. PUBMED:3047871 EPMC:3047871

  4. Saxe CL 3rd, Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR; , Genes Dev 1993;7:262-272.: CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum. PUBMED:8436297 EPMC:8436297


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(6)
Full
(214)
Representative proteomes NCBI
(697)
Meta
(4)
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(74)
RP35
(115)
RP55
(151)
RP75
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  Seed
(6)
Full
(214)
Representative proteomes NCBI
(697)
Meta
(4)
RP15
(74)
RP35
(115)
RP55
(151)
RP75
(165)
Alignment:
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  Seed
(6)
Full
(214)
Representative proteomes NCBI
(697)
Meta
(4)
RP15
(74)
RP35
(115)
RP55
(151)
RP75
(165)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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Seed source: Pfam-B_16614 (release 8.0)
Previous IDs: Dict_CAR;
Type: Family
Author: Moxon SJ
Number in seed: 6
Number in full: 214
Average length of the domain: 215.50 aa
Average identity of full alignment: 19 %
Average coverage of the sequence by the domain: 52.21 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.0 20.0
Trusted cut-off 20.0 20.0
Noise cut-off 19.9 19.9
Model length: 305
Family (HMM) version: 6
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